Cer response to aromatase inhibition. Nature 486, 35360. Heintzman, N.D., Stuart, R.K., Hon, G., Fu, Y., Ching, C.W., Hawkins, R.D., Barrera, L.O., Van Calcar, S., Qu, C., Ching, K.A., et al. (2007). Distinct and predictive chromatin signatures of transcriptional promoters and enhancers in the human genome. Nat. Genet. 39, 31118. Heintzman, N.D., Hon, G.C., Hawkins, R.D., Kheradpour, P., Stark, A., Harp, L.F., Ye, Z., Lee, L.K., Stuart, R.K., Ching, C.W., et al. (2009). Histone2722 Cell Reports 17, 2715723, December six,modifications at human enhancers reflect global cell-type-specific gene expression. Nature 459, 10812. Herz, H.M., Mohan, M., Garruss, A.S., Liang, K., Takahashi, Y.H., Mickey, K., Voets, O., Verrijzer, C.P., and Shilatifard, A. (2012). Enhancer-associated H3K4 monomethylation by Trithorax-related, the Drosophila homolog of mammalian Mll3/Mll4. Genes Dev. 26, 2604620. Hurtado, A., Holmes, K.A., Ross-Innes, C.S., Schmidt, D., and Carroll, J.S. (2011). FOXA1 is often a important determinant of estrogen receptor function and endocrine response. Nat. Genet. 43, 273. Jozwik, K.M., and Carroll, J.S. (2012). Pioneer aspects in hormone-dependent cancers. Nat. Rev. Cancer 12, 38185.885270-86-0 Price Livak, K.J., and Schmittgen, T.D. (2001). Analysis of relative gene expression data utilizing real-time quantitative PCR as well as the two(-Delta Delta C(T)) approach. Solutions 25, 40208. Lupien, M., Eeckhoute, J., Meyer, C.A., Wang, Q., Zhang, Y., Li, W., Carroll, J.S., Liu, X.S., and Brown, M. (2008). FoxA1 translates epigenetic signatures into enhancer-driven lineage-specific transcription. Cell 132, 95870. Mohammed, H., D’Santos, C., Serandour, A.A., Ali, H.R., Brown, G.D., Atkins, A., Rueda, O.M., Holmes, K.A., Theodorou, V., Robinson, J.L.L., et al. (2013). Endogenous purification reveals GREB1 as a important estrogen receptor regulatory element. Cell Rep. 3, 34249. Robinson, J.L.L., Macarthur, S., Ross-Innes, C.S., Tilley, W.D., Neal, D.E., Mills, I.G., and Carroll, J.S. (2011). Androgen receptor driven transcription in molecular apocrine breast cancer is mediated by FoxA1. EMBO J. 30, 30193027. Sahu, B., Laakso, M., Ovaska, K., Mirtti, T., Lundin, J., Rannikko, A., Sankila, A., Turunen, J.-P., Lundin, M., Konsti, J., et al. (2011). Dual function of FoxA1 in androgen receptor binding to chromatin, androgen signalling and prostate cancer. EMBO J. 30, 3962976.Schmidt, D., Wilson, M.D., Spyrou, C., Brown, G.D., Hadfield, J., and Odom, D.T. (2009). ChIP-seq: making use of high-throughput sequencing to find out protein-DNA interactions.(S)-Tetrahydrofuran-3-carboxylic acid In stock Procedures 48, 24048.PMID:24957087 Serandour, A.A., Avner, S., Percevault, F., Demay, F., Bizot, M., Lucchetti-Miganeh, C., Barloy-Hubler, F., Brown, M., Lupien, M., Metivier, R., et al. (2011). Epigenetic switch involved in activation of pioneer factor FOXA1-dependent enhancers. Genome Res. 21, 55565. Stark, R., and Brown, G. (2011). DiffBind: differential binding analysis of ChIPSeq peak information. http://bioconductor.org/packages/release/bioc/vignettes/ DiffBind/inst/doc/DiffBind.pdf. Vermeulen, M., and Timmers, H.T.M. (2010). Grasping trimethylation of histone H3 at lysine four. Epigenomics 2, 39506. Wang, X.-X., Fu, L., Li, X., Wu, X., Zhu, Z., Fu, L., and Dong, J.-T. (2011). Somatic mutations of your mixed-lineage leukemia 3 (MLL3) gene in primary breast cancers. Pathol. Oncol. Res. 17, 42933. Werner, S., Frey, S., Riethdorf, S., Schulze, C., Alawi, M., Kling, L., Vafaizadeh, V., Sauter, G., Terracciano, L., Schumacher, U., et al. (2013). Dual roles of your transcription issue grain.